8-Dimetilalilnaringenin 2'-hidroksilaza
(Preusmjereno sa stranice 8-dimetilalilnaringenin 2'-hidroksilaza)
| 8-Dimetilalilnaringenin 2'-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.103 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
8-Dimetilalilnaringenin 2'-hidroksilaza (EC 1.14.13.103, 8-DMAN 2'-hidroksilaza) je enzim sa sistematskim imenom soforaflavanon-B,NADPH:kiseonik oksidoreduktaza (2'-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- soforaflavanon B + NADPH + H+ + O2 leahianon G + NADP+ + H2O
Ovaj za membranu vezani hem-tiolatni protein je asociran sa endoplazmičnim retikulumom. On je specifičan za soforaflavanon B kao supstrat. NADPH se ne može zameniti drugim kofaktorima.
Reference[uredi | uredi kod]
- ↑ Yamamoto, H., Yatou, A. and Inoue, K. (2001). „8-Dimethylallylnaringenin 2′-hydroxylase, the crucial cytochrome P450 mono-oxygenase for lavandulylated flavanone formation in Sophora flavescens cultured cells”. Phytochemistry 58: 671-676. PMID 11672730.
- ↑ Zhao, P., Inoue, K., Kouno, I. and Yamamoto, H. (2003). „Characterization of leachianone G 2′′-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait. cell suspension cultures”. Plant Physiol. 133: 1306-1313. PMID 14551337.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.