8-Hidroksifuranokumarin 8-O-metiltransferaza
| 8-hidroksifuranokumarin 8-O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.70 | ||||||||
| CAS broj | 67339-13-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
8-hidroksifuranokumarin 8-O-metiltransferaza (EC 2.1.1.70, furanokumarinska 8-metiltransferaza, furanokumarinska 8-O-metil-transferaza, ksantotoksolna 8-O-metiltransferaza, XMT, 8-hidroksifuranokumarinska 8-O-metiltransferaza, SAM:ksantotoksol O-metiltransferaza, S-adenozil-L-metionin:8-hidroksifuranokumarin 8-O-metiltransferaza, ksantotoksolna metiltransferaza, ksantotoksolna O-metiltransferaza, S-adenozil-L-metionin:ksantotoksol O-metiltransferaza, S-adenozil-L-metionin-ksantotoksolna O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:8-hidroksifurokumarin 8-O-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) S-adenozil-L-metionin + 8-hidroksifurokumarin S-adenozil-L-homocistein + 8-metoksifurokumarin (opšta reakcija)
- (2) S-adenozil-L-metionin + ksantotoksol S-adenozil-L-homocistein + ksantotoksin
Enzim konvertuje ksantotoksol u ksantotoksin, koji ima terapeutski potencijal u treatmanu psorijaze.
Reference[uredi | uredi kod]
- ↑ Thompson, H.J., Sharma, S.K. and Brown, S.A. (1978). „O-Methyltransferases of furanocoumarin biosynthesis”. Arch. Biochem. Biophys. 188: 272-281. PMID 28084.
- ↑ Hauffe, K.D., Hahlbrock, K. and Scheel, D. (1986). „Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases”. Z. Naturforsch. C: Biosci. 41: 228-239.
- ↑ Sharma, S.K., Garrett, J.M. and Brown, S.A. (1979). „Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography”. Z. Naturforsch. [C] 34C: 387-391. PMID 156999.
- ↑ Hehmann, M., Lukačin, R., Ekiert, H. and Matern, U. (2004). „Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase”. Eur. J. Biochem. 271: 932-940. PMID 15009205.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.