7a-hidroksisteroid dehidrogenaza
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| 7a-hidroksisteroid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.159 | ||||||||
| CAS broj | 39361-64-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
7a-hidroksisteroid dehidrogenaza (EC 1.1.1.159, 7alfa-hidroksi steroidna dehidrogenaza, 7alfa-HSDH) je enzim sa sistematskim imenom 7alfa-hidroksisteroid:NAD+ 7-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- holat + NAD+ 3alfa,12alfa-dihidroksi-7-okso-5beta-holan-24-oat + NADH + H+
7a-Hidroksisteroidna dehidrogenaza katalizuje oksidaciju 7alfa-hidroksi grupa žučne kiseline i alkohola u njihovim slobodnim i konjugovanim formama. Bacteroides fragilis i Clostridium enzimi takođe mogu da koriste NADP+.
Reference[uredi | uredi kod]
- ↑ Haslewood, E.S. and Haslewood, G.A.D. (1976). „The specificity of a 7α-hydroxy steroid dehydrogenase from Escherichia coli”. Biochem. J. 157: 207-210. PMID 786279.
- ↑ Macdonald, I.A. and Roach, P.D. (1981). „Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum”. Biochim. Biophys. Acta 665: 262-269. PMID 6945134.
- ↑ Macdonald, I.A., Williams, C.N. and Mahony, D.E. (1973). „7α-Hydroxysteroid dehydrogenase from Escherichia coli B: preliminary studies”. Biochim. Biophys. Acta 309: 243-253. PMID 4581498.
- ↑ Macdonald, I.A., Williams, C.N., Mahony, D.E. and Christie, W.M. (1975). „NAD- and NADP-dependent 7α-hydroxysteroid dehydrogenases from Bacteroides fragilis”. Biochim. Biophys. Acta 384: 12-24. PMID 236764.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.