7-Metilksantozin sintaza

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7-Metilksantozin sintaza
Identifikatori
EC broj 2.1.1.158
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

7-Metilksantozin sintaza (EC 2.1.1.158, ksantozinska metiltransferaza, XMT, ksantozin:S-adenozil-L-metionin metiltransferaza, CtCS1, CmXRS1, CaXMT1, S-adenozil-L-metionin:ksantozin 7-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:ksantozin N7-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + ksantozin S-adenozil-L-homocistein + 7-metilksantozin

Ovaj enzim je specifičan za ksantozin. XMP i ksantin nisu supstrati.

Reference[uredi - уреди | uredi izvor]

  1. Negishi, O., Ozawa, T. and Imagawa, H. (1985). "The role of xanthosine in the biosynthesis of caffeine in coffee plants". Agric. Biol. Chem. 49: 2221–2222. 
  2. Mizuno, K., Kato, M., Irino, F., Yoneyama, N., Fujimura, T. and Ashihara, H. (2003). "The first committed step reaction of caffeine biosynthesis: 7-methylxanthosine synthase is closely homologous to caffeine synthases in coffee (Coffea arabica L.)". FEBS Lett. 547: 56–60. PMID 12860386. 
  3. Uefuji, H., Ogita, S., Yamaguchi, Y., Koizumi, N. and Sano, H. (2003). "Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants". Plant Physiol. 132: 372–380. PMID 12746542. 
  4. Yoneyama, N., Morimoto, H., Ye, C.X., Ashihara, H., Mizuno, K. and Kato, M. (2006). "Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme". Mol. Genet. Genomics 275: 125–135. PMID 16333668. 

Literatura[uredi - уреди | uredi izvor]

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