6-Hidroksi-3-sukcinoilpiridin 3-monooksigenaza
(Preusmjereno sa stranice 6-hidroksi-3-sukcinoilpiridin 3-monooksigenaza)
| 6-Hidroksi-3-sukcinoilpiridin 3-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.163 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
6-Hidroksi-3-sukcinoilpiridin 3-monooksigenaza (EC 1.14.13.163, 6-hidroksi-3-sukcinoilpiridinska hidroksilaza, hspA (gen), hspB (gen)) je enzim sa sistematskim imenom 4-(6-hidroksipiridin-3-il)-4-oksobutanoat,NADH:kiseonik oksidoreduktaza (3-hidroksilacija, sukcinat semialdehidno otpuštanje).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-(6-hidroksipiridin-3-il)-4-oksobutanoat + 2 NADH + 2 H+ + O2 2,5-dihidroksipiridin + sukcinat semialdehid + 2 NAD+ + H2O
Ovaj enzim učestvuje u degradaciji nikotina kod Pseudomonas species.
Reference[uredi | uredi kod]
- ↑ Tang, H., Wang, S., Ma, L., Meng, X., Deng, Z., Zhang, D., Ma, C. and Xu, P. (2008). „A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16”. Appl. Environ. Microbiol. 74: 1567-1574. PMID 18203859.
- ↑ Tang, H., Yao, Y., Zhang, D., Meng, X., Wang, L., Yu, H., Ma, L. and Xu, P. (2011). „A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida”. J. Biol. Chem. 286: 39179-39187. PMID 21949128.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.