6-Oksokamforna hidrolaza

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6-Oksokamforna hidrolaza
Identifikatori
EC broj 3.7.1.18
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

6-Oksokamforna hidrolaza (EC 3.7.1.18, OCH, camK (gen)) je enzim sa sistematskim imenom bornan-2,6-dion hidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

bornan-2,6-dion + H2O [(1S)-4-hidroksi-2,2,3-trimetilciklopent-3-enil]acetat

Ovaj enzim je izolovan iz Rhodococcus sp.

Reference[uredi - уреди | uredi izvor]

  1. Grogan, G., Roberts, G.A., Bougioukou, D., Turner, N.J. and Flitsch, S.L. (2001). "The desymmetrization of bicyclic β-diketones by an enzymatic retro-Claisen reaction. A new reaction of the crotonase superfamily". J. Biol. Chem. 276: 12565–12572. PMID 11278926. 
  2. Whittingham, J.L., Turkenburg, J.P., Verma, C.S., Walsh, M.A. and Grogan, G. (2003). "The 2-Å crystal structure of 6-oxo camphor hydrolase. New structural diversity in the crotonase superfamily". J. Biol. Chem. 278: 1744–1750. PMID 12421807. 
  3. Leonard, P.M. and Grogan, G. (2004). "Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-α-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homolog". J. Biol. Chem. 279: 31312–31317. PMID 15138275. 

Literatura[uredi - уреди | uredi izvor]

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