6-Oksokamforna hidrolaza
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| 6-Oksokamforna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.7.1.18 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
6-Oksokamforna hidrolaza (EC 3.7.1.18, OCH, camK (gen)) je enzim sa sistematskim imenom bornan-2,6-dion hidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- bornan-2,6-dion + H2O [(1S)-4-hidroksi-2,2,3-trimetilciklopent-3-enil]acetat
Ovaj enzim je izolovan iz Rhodococcus sp.
Reference[uredi | uredi kod]
- ↑ Grogan, G., Roberts, G.A., Bougioukou, D., Turner, N.J. and Flitsch, S.L. (2001). „The desymmetrization of bicyclic β-diketones by an enzymatic retro-Claisen reaction. A new reaction of the crotonase superfamily”. J. Biol. Chem. 276: 12565-12572. PMID 11278926.
- ↑ Whittingham, J.L., Turkenburg, J.P., Verma, C.S., Walsh, M.A. and Grogan, G. (2003). „The 2-Å crystal structure of 6-oxo camphor hydrolase. New structural diversity in the crotonase superfamily”. J. Biol. Chem. 278: 1744-1750. PMID 12421807.
- ↑ Leonard, P.M. and Grogan, G. (2004). „Structure of 6-oxo camphor hydrolase H122A mutant bound to its natural product, (2S,4S)-α-campholinic acid: mutant structure suggests an atypical mode of transition state binding for a crotonase homolog”. J. Biol. Chem. 279: 31312-31317. PMID 15138275.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.