5-Metiltetrahidrofolat:korinoid/gvožđe-sumpor protein Co-metiltransferaza
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| 5-Metiltetrahidrofolat:korinoid/gvožđe-sumpor protein Co-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.258 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
5-Metiltetrahidrofolat:korinoid/gvožđe-sumpor protein Co-metiltransferaza (EC 2.1.1.258, acsE (gen)) je enzim sa sistematskim imenom 5-metiltetrahidrofolat:korinoid/gvožđe-sumporna proteinska metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- [metil-Co(III) korinoidni Fe-S protein] + tetrahidrofolat [Co(I) korinoidni Fe-S protein] + 5-metiltetrahidrofolat
Ovaj enzim katalizuje transfer metil grupe sa N5 pozicije metiltetrahidrofolata na 5-metoksibenzimidazolilkobamidni kofaktor korinoid/Fe-S proteina.
Reference[uredi | uredi kod]
- ↑ Roberts, D.L., Zhao, S., Doukov, T. and Ragsdale, S.W. (1994). „The reductive acetyl coenzyme A pathway: sequence and heterologous expression of active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum”. J. Bacteriol. 176: 6127-6130. PMID 7928975.
- ↑ Doukov, T., Seravalli, J., Stezowski, J.J. and Ragsdale, S.W. (2000). „Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase”. Structure 8: 817-830. PMID 10997901.
- ↑ Doukov, T.I., Hemmi, H., Drennan, C.L. and Ragsdale, S.W. (2007). „Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases”. J. Biol. Chem. 282: 6609-6618. PMID 17172470.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.