4-metoksibenzoat monooksigenaza (O-demetilacija)
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| 4-metoksibenzoat monooksigenaza (O-demetilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.15 | ||||||||
| CAS broj | 37256-78-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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4-metoksibenzoat monooksigenaza (O-demetilacija) (EC 1.14.99.15, 4-metoksibenzoatna 4-monooksigenaza (O-demetilacija), 4-metoksibenzoatna O-demetilaza, p-anisonska O-demetilaza, piperonilat-4-O-demetilaza) je enzim sa sistematskim imenom 4-metoksibenzoat,vodonik-donor:kiseonik oksidoreduktaza (O-demetilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-metoksibenzoat + AH2 + O2 4-hidroksibenzoat + formaldehid + A + H2O
Ovaj bakterijski enzim sadrži feredoksinski tip proteina i gvožđe-sumporni flavoprotein (FMN). On takođe deluje na 4-etoksibenzoat, N-metil-4-aminobenzoat i toluate.
Reference[uredi | uredi kod]
- ↑ Bernhardt, F.-H., Nastainczyk, W. and Seydewitz, V. (1977). „Kinetic studies on a 4-methoxybenzoate O-demethylase from Pseudomonas putida”. Eur. J. Biochem. 72: 107-115. PMID 188654.
- ↑ Paszcynski, A. and Trojanowski, J. (1977). „An affinity-column procedure for the purification of veratrate O-demethylase from fungi”. Microbios 18: 111-121. PMID 25369.
- ↑ Twilfer, H., Bernhardt, F.-H. and Gersonde, K. (1981). „An electron-spin-resonance study on the redox-active centers of the 4-methoxybenzoate monooxygenase from Pseudomonas putida”. Eur. J. Biochem. 119: 595-602. PMID 6273164.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.