4-fosfoeritronat dehidrogenaza
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| 4-fosfoeritronat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.290 | ||||||||
| CAS broj | 125858-75-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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4-fosfoeritronat dehidrogenaza (EC 1.1.1.290, PdxB, PdxB 4PE dehidrogenaza, 4-O-fosfoeritronatna dehidrogenaza) je enzim sa sistematskim imenom 4-fosfo-D-eritronat:NAD+ 2-oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-fosfo-D-eritronat + NAD+ (3R)-3-hidroksi-2-okso-4-fosfonooksibutanoat + NADH + H+
Ovaj enzim katalizuje drugi korak biosinteze koenzima piridoksal 5'-fosfat u bakteriji Escherichia coli. Reakcija se predominatno odvija u reverznom smeru. Drugi enzimi ovog biosintetičkog puta su: EC 1.2.1.72 (eritroza-4-fosfat dehidrogenaza), EC 2.6.1.52 (fosfoserin transaminaza), EC 1.1.1.262 (4-hidroksitreonin-4-fosfat dehidrogenaza), EC 2.6.99.2 (piridoksin 5'-fosfat sintaza) i EC 1.4.3.5 (piridoksamin-fosfat oksidaza).
Reference[uredi | uredi kod]
- ↑ Lam, H.M. and Winkler, M.E. (1990). „Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12”. J. Bacteriol. 172: 6518-6528. PMID 2121717.
- ↑ Pease, A.J., Roa, B.R., Luo, W. and Winkler, M.E. (2002). „Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12”. J. Bacteriol. 184: 1359-1369. PMID 11844765.
- ↑ Zhao, G. and Winkler, M.E. (1996). „A novel α-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria”. J. Bacteriol. 178: 232-239. PMID 8550422.
- ↑ Grant, G.A. (1989). „A new family of 2-hydroxyacid dehydrogenases”. Biochem. Biophys. Res. Commun. 165: 1371-1374. PMID 2692566.
- ↑ Schoenlein, P.V., Roa, B.B. and Winkler, M.E. (1989). „Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12”. J. Bacteriol. 171: 6084-6092. PMID 2681152.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.