4-Hidroksifenilacetatna dekarboksilaza
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| 4-Hidroksifenilacetatna dekarboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.1.83 | ||||||||
| CAS broj | 340137-18-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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4-Hidroksifenilacetatna dekarboksilaza (EC 4.1.1.83, p-hidroksifenilacetatna dekarboksilaza, p-Hpd, 4-Hpd, 4-hidroksifenilacetatna karboksilijaza) je enzim sa sistematskim imenom 4-(hidroksifenil)acetat karboksilijaza (formira 4-metilfenol).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (4-hidroksifenil)acetat + H+ 4-metilfenol + CO2
Enzim iz anaerobne Clostridium difficile takođe može da koristi (3,4-dihidroksifenil)acetat kao supstrat, pri čemu se formira 4-metilkatehol kao produkt.
Reference[uredi | uredi kod]
- ↑ D'Ari, L. and Barker, H.A. (1985). „p-Cresol formation by cell-free extracts of Clostridium difficile”. Arch. Microbiol. 143: 311-312. PMID 3938267.
- ↑ Selmer, T. and Andrei, P.I. (2001). „p-Hydroxyphenylacetate decarboxylase from Clostridium difficile. A novel glycyl radical enzyme catalysing the formation of p-cresol”. Eur. J. Biochem. 268: 1363-1372. PMID 11231288.
- ↑ Andrei, P.I., Pierik, A.J., Zauner, S., Andrei-Selmer, L.C. and Selmer, T. (2004). „Subunit composition of the glycyl radical enzyme p-hydroxyphenylacetate decarboxylase. A small subunit, HpdC, is essential for catalytic activity”. Eur. J. Biochem. 271: 2225-2230. PMID 15153112.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.