4-Hidroksi-2-oksovaleratna aldolaza
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| 4-Hidroksi-2-oksovaleratna aldolaza | |||||||||
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| 4-Hidroksi-2-oksovaleratna aldolaza heterotetramer, Pseudomonas | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.3.39 | ||||||||
| CAS broj | 37325-52-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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4-Hidroksi-2-oksovaleratna aldolaza (EC 4.1.3.39, 4-hidroksi-2-ketovaleratna aldolaza, HOA, DmpG, 4-hidroksi-2-oksovaleratna piruvat-lijaza, 4-hidroksi-2-oksopentanoat piruvat-lijaza) je enzim sa sistematskim imenom 4-hidroksi-2-oksopentanoat piruvat-lijaza (formira acetaldehid).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-hidroksi-2-oksopentanoat acetaldehid + piruvat
Za maksimalno dejstvo ovog enzima je neophodan jon Mn2+.
Reference[uredi | uredi kod]
- ↑ Manjasetty, B.A., Powlowski, J. and Vrielink, A. (2003). „Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate”. Proc. Natl. Acad. Sci. USA 100: 6992-6997. PMID 12764229.
- ↑ Powlowski, J., Sahlman, L. and Shingler, V. (1993). „Purification and properties of the physically associated meta-cleavage pathway enzymes 4-hydroxy-2-ketovalerate aldolase and aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600”. J. Bacteriol. 175: 377-385. PMID 8419288.
- ↑ Manjasetty, B.A., Croteau, N., Powlowski, J. and Vrielink, A. (2001). „Crystallization and preliminary X-ray analysis of dmpFG-encoded 4-hydroxy-2-ketovalerate aldolase—aldehyde dehydrogenase (acylating) from Pseudomonas sp. strain CF600”. Acta Crystallogr. D Biol. Crystallogr. 57: 582-585. PMID 11264589.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.