4-(Citidin 5'-difosfo)-2-C-metil-D-eritritol kinaza
(Preusmjereno sa stranice 4-(citidin 5'-difosfo)-2-C-metil-D-eritritol kinaza)
| 4-(Citidin 5'-difosfo)-2-C-metil-D-eritritol kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.148 | ||||||||
| CAS broj | 263016-77-9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
4-(Citidin 5'-difosfo)-2-C-metil-D-eritritol kinaza (EC 2.7.1.148, CDP-ME kinaza) je enzim sa sistematskim imenom ATP:4-(citidin 5'-difosfo)-2-C-metil-D-eritritol 2-fosfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + 4-(citidin 5'-difosfo)-2-C-metil-D-eritritol ADP + 2-fosfo-4-(citidin 5'-difosfo)-2-C-metil-D-eritritol
Za rad enzima iz Escherichia coli je neophodan jon Mg2+ ili Mn2+.
Reference[uredi | uredi kod]
- ↑ Lüttgen, H., Rohdich, F., Herz, S., Wungsintaweekul, J., Hecht, S., Schuhr, C.A., Fellermeier, M., Sagner, S., Zenk, M.H., Bacher, A. and Eisenreich, W. (2000). „Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erithritol”. Proc. Natl. Acad. Sci. USA 97: 1062-1067. PMID 10655484.
- ↑ Kuzuyama, T., Takagi, M., Kaneda, K., Watanabe, H., Dairi, T. and Seto, H. (2000). „Studies on the nonmevalonate pathway: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase”. Tetrahedron Lett. 41: 2925-2928.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.