3-okso-5a-steroid 4-dehidrogenaza
| 3-okso-5a-steroid 4-dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.5 | ||||||||
| CAS broj | 9036-43-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3-okso-5a-steroid 4-dehidrogenaza (EC 1.3.99.5, steroid 5alfa-reduktaza, 3-oksosteroid Delta4-dehidrogenaza, 3-okso-5alfa-steroid Delta4-dehidrogenaza, steroid Delta4-5alfa-reduktaza, Delta4-3-keto steroid 5alfa-reduktaza, Delta4-3-okso steroid reduktaza, Delta4-3-ketosteroid5alfa-oksidoreduktaza, Delta4-3-oksosteroid-5alfa-reduktaza, 3-keto-Delta4-steroid-5alfa-reduktaza, 5alfa-reduktaza, testosteron 5alfa-reduktaza, 4-en-3-ketosteroid-5alfa-oksidoreduktaza, Delta4-5alfa-dehidrogenaza, 3-okso-5alfa-steroid:(akceptor) Delta4-oksidoreduktaza, tesI (gen)) je enzim sa sistematskim imenom 3-okso-5alfa-steroid:akceptor Delta4-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3-okso-5alfa-steroid + akceptor 3-okso-Delta4-steroid + redukovani akceptor
Ovaj enzim je flavoprotein. Ovaj bakterijski enzim je karakterizovan iz Comamonas testosteroni. On učestvuje u androsteronskog degradaciji, cf. EC 1.3.1.22, 3-okso-5alfa-steroid 4-dehidrogenaza (NADP+).
Reference[uredi | uredi kod]
- ↑ Levy, H.R. and Talalay, P. (1959). „Bacterial oxidation of steroids. II. Studies on the enzymatic mechanisms of ring A dehydrogenation”. J. Biol. Chem. 234: 2014-2021. PMID 13673006.
- ↑ Florin, C., Kohler, T., Grandguillot, M. and Plesiat, P. (1996). „Comamonas testosteroni 3-ketosteroid-Δ4(5α)-dehydrogenase: gene and protein characterization”. J. Bacteriol. 178: 3322-3330. PMID 8655514.
- ↑ Horinouchi, M., Hayashi, T., Yamamoto, T. and Kudo, T. (2003). „A new bacterial steroid degradation gene cluster in Comamonas testosteroni TA441 which consists of aromatic-compound degradation genes for seco-steroids and 3-ketosteroid dehydrogenase genes”. Appl. Environ. Microbiol. 69: 4421-4430. PMID 12902225.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.