3-Fenilpropionat dioksigenaza
(Preusmjereno sa stranice 3-fenilpropionat dioksigenaza)
| 3-Fenilpropionat dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.12.19 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3-Fenilpropionat dioksigenaza (EC 1.14.12.19, HcaA1A2CD, Hca dioksigenaza, 3-fenilpropionatna dioksigenaza) je enzim sa sistematskim imenom 3-fenilpropanoat,NADH:kiseonik oksidoreduktaza (2,3-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 3-fenilpropanoat + NADH + H+ + O2 3-(cis-5,6-dihidroksicikloheksa-1,3-dien-1-il)propanoat + NAD+
- (2) (2E)-3-fenilprop-2-enoat + NADH + H+ + O2 (2E)-3-(2,3-dihidroksifenil)prop-2-enoat + NAD+
Ovaj enzim učestvuje u degradaciji fenilpropanoidnih jedinjenja. On katalizuje umetanje oba atoma molekulskog kiseonika u pozicije 2 i 3 fenilnog prstena 3-fenilpropanoat ili (2E)-3-fenilprop-2-enoata.
Reference[uredi | uredi kod]
- ↑ Díaz, E., Ferrández, A. and García, J.L. (1998). „Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12”. J. Bacteriol. 180: 2915-2923. PMID 9603882.
- ↑ Burlingame, R. and Chapman, P.J. (1983). „Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli”. J. Bacteriol. 155: 113-121. PMID 6345502.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.