3-Izopropilmalatna dehidrataza
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| 3-Izopropilmalatna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.33 | ||||||||
| CAS broj | 37290-72-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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3-Izopropilmalatna dehidrataza (EC 4.2.1.33, (2R,3S)-3-izopropilmalatna hidrolijaza, beta-izopropilmalatna dehidrataza, izopropilmalatna izomeraza, alfa-izopropilmalatna izomeraza, 3-izopropilmalatna hidrolijaza) je enzim sa sistematskim imenom (2R,3S)-3-izopropilmalat hidrolijaza (formira 2-izopropilmaleat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2R,3S)-3-izopropilmalat (2S)-2-izopropilmalat (sveukupna reakcija)
- (1a) (2R,3S)-3-izopropilmalat 2-izopropilmaleat + H2O
- (1b) 2-izopropilmaleat + H2O (2S)-2-izopropilmalat
Ovaj enzim učestvuje u biosintezi leucina.
Reference[uredi | uredi kod]
- ↑ Gross, S.R., Burns, R.O. and Umbarger, H.E. (1963). „The biosynthesis of leucine. II. The enzymic isomerization of β-carboxy-β-hydroxyisocaproate and α-hydroxy-β-carboxyisocaproate”. Biochemistry 2: 1046-1052. PMID 14087357.
- ↑ Calvo, J. (1964). „M., Stevens, C. M., Kalyanpur, M. G., and Umbarger, H. E. The absolute configuration of α-hydroxy-β-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis”. Biochemistry 3: 2024-2027. PMID 14269331.
- ↑ Cole, F.E., Kalyanpur, M. (1973). „G. and Stevens, C. M. Absolute configuration of α-isopropylmalate and the mechanism of its conversion to β-isopropylmalate in the biosynthesis of leucine”. Biochemistry 12: 3346-3350. PMID 4270046.
- ↑ Jang, S. and Imlay, J.A. (2007). „Micromolar intracellular hydrogen peroxide disrupts metabolism by damaging iron-sulfur enzymes”. J. Biol. Chem. 282: 929-937. PMID 17102132.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.