3,5,7-Trioksododekanoil-KoA sintaza
(Preusmjereno sa stranice 3,5,7-trioksododekanoil-KoA sintaza)
| 3,5,7-Trioksododekanoil-KoA sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.206 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3,5,7-Trioksododekanoil-KoA sintaza (EC 2.3.1.206, TKS, olivetolna sintaza) je enzim sa sistematskim imenom malonil-KoA:heksanoil-KoA maloniltransferaza (formira 3,5,7-trioksododekanoil-KoA).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3 malonil-KoA + heksanoil-KoA 3 KoA + 3,5,7-trioksododekanoil-KoA + 3 CO2
Ova poliketidna sintaza katalizuje prvi korak u biodintezi kanabinoida u biljci Cannabis sativa.
Reference[uredi | uredi kod]
- ↑ Taura, F., Tanaka, S., Taguchi, C., Fukamizu, T., Tanaka, H., Shoyama, Y. and Morimoto, S. (2009). „Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway”. FEBS Lett 583: 2061-2066. PMID 19454282.
- ↑ Gagne, S.J., Stout, J.M., Liu, E., Boubakir, Z., Clark, S.M. and Page, J.E. (2012). „Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides”. Proc. Natl. Acad. Sci. USA 109: 12811-12816. PMID 22802619.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.