23S rRNK pseudouridinska1911/1915/1917 sintaza
Prijeđi na navigaciju
Prijeđi na pretragu
| 23S rRNK pseudouridinska1911/1915/1917 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.23 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
23S rRNK pseudouridinska1911/1915/1917 sintaza (EC 5.4.99.23, RluD, pseudouridinska sintaza RluD) je enzim sa sistematskim imenom 23S rRNK-uridin1911/1915/1917 uracil mutaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 23S rRNK uridin1911/uridin1915/uridin1917 23S rRNK pseudouridin1911/pseudouridin1915/pseudouridin1917
Pseudouridinska sintaza RluD konvertuje uridine u pozicijama 1911, 1915, i 1917 molekula 23S rRNK do pseudouridina.
Reference[uredi | uredi kod]
- ↑ Leppik, M., Peil, L., Kipper, K., Liiv, A. and Remme, J. (2007). „Substrate specificity of the pseudouridine synthase RluD in Escherichia coli”. FEBS J. 274: 5759-5766. PMID 17937767.
- ↑ Ejby, M., Sorensen, M.A. and Pedersen, S. (2007). „Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination”. Proc. Natl. Acad. Sci. USA 104: 19410-19415. PMID 18032607.
- ↑ Sivaraman, J., Iannuzzi, P., Cygler, M. and Matte, A. (2004). „Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli”. J. Mol. Biol. 335: 87-101. PMID 14659742.
- ↑ Wrzesinski, J., Bakin, A., Ofengand, J. and Lane, B.G. (2000). „Isolation and properties of Escherichia coli 23S-RNA pseudouridine 1911, 1915, 1917 synthase (RluD)”. IUBMB Life 50: 33-37. PMID 11087118.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.