2-Metilcitrat sintaza
(Preusmjereno sa stranice 2-metilcitrat sintaza)
| 2-Metilcitrat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.3.5 | ||||||||
| CAS broj | 57827-78-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Metilcitrat sintaza (EC 2.3.3.5, 2-metilcitrat oksaloacetatna lijaza, MCS, metilcitratna sintaza, metilcitratna sintetaza) je enzim sa sistematskim imenom propanoil-KoA:oksaloacetat C-propanoiltransferaza (tioestarska hidroliza, formiranje 1-karboksietila).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- propanoil-KoA + H2O + oksaloacetat (2R,3S)-2-hidroksibutan-1,2,3-trikarboksilat + KoA
Ovaj enzim deluje na acetil-KoA, propanoil-KoA, butanoil-KoA i pentanoil-KoA.
Reference[uredi | uredi kod]
- ↑ Uchiyama, H. and Tabuchi, T. (1976). „Properties of methylcitrate synthase from Candida lipolytica”. Agric. Biol. Chem. 40: 1411-1418.
- ↑ Textor, S., Wendisch, V.F., De Graaf, A.A., Muller, U., Linder, M.I., Linder, D. and Buckel, W. (1997). „Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria”. Arch. Microbiol. 168: 428-436. PMID 9325432.
- ↑ Horswill, A.R. and Escalante-Semerena, J.C. (1999). „Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle”. J. Bacteriol. 181: 5615-5623. PMID 10482501.
- ↑ van Rooyen, J.P., Mienie, L.J., Erasmus, E., De Wet, W.J., Ketting, D., Duran, M. and Wadman, S.K. (1994). „Identification of the stereoisomeric configurations of methylcitric acid produced by Si-citrate synthase and methylcitrate synthase using capillary gas chromatography-mass spectrometry”. J. Inherit. Metab. Dis. 17: 738-747. PMID 7707698.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.