2-Hidroksipropil-KoM lijaza
(Preusmjereno sa stranice 2-hidroksipropil-KoM lijaza)
| 2-Hidroksipropil-KoM lijaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.4.1.23 | ||||||||
| CAS broj | 244301-07-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Hidroksipropil-KoM lijaza (EC 4.4.1.23, epoksialkan:koenzim M transferaza, epoksialkan:KoM transferaza, epoksialkan:2-merkaptoetansulfonatna transferaza, koenzim M-epoksialkanska ligaza, epoksialkil:KoM transferaza, epoksipropan:koenzim M transferaza, epoksipropil:KoM transferaza, EaKoMT, 2-hidroksipropil-KoM:2-merkaptoetansulfonat lijaza (formira epoksialkanski prsten), (R)-2-hidroksipropil-KoM 2-merkaptoetansulfonatna lijaza (ciklizacija, formira (R)-1,2-epoksipropan)) je enzim sa sistematskim imenom (R)-(ili (S)-)2-hidroksipropil-KoM:2-merkaptoetansulfonat lijaza (formira epoksialkanski prsten).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) (R)-2-hidroksipropil-KoM (R)-1,2-epoksipropan + HS-KoM
- (2) (S)-2-hidroksipropil-KoM (S)-1,2-epoksipropan + HS-KoM
Za dejstvo ovog enzima je neophodan cink.
Reference[uredi | uredi kod]
- ↑ Allen, J.R., Clark, D.D., Krum, J.G. and Ensign, S.A. (1999). „A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation”. Proc. Natl. Acad. Sci. USA 96: 8432-8437. PMID 10411892.
- ↑ Krum, J.G., Ellsworth, H., Sargeant, R.R., Rich, G. and Ensign, S.A. (2002). „Kinetic and microcalorimetric analysis of substrate and cofactor interactions in epoxyalkane:CoM transferase, a zinc-dependent epoxidase”. Biochemistry 41: 5005-5014. PMID 11939797.
- ↑ Coleman, N.V. and Spain, J.C. (2003). „Epoxyalkane: coenzyme M transferase in the ethene and vinyl chloride biodegradation pathways of Mycobacterium strain JS60”. J. Bacteriol. 185: 5536-5545. PMID 12949106.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.