2-hidroksietilfosfonat dioksigenaza
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| 2-hidroksietilfosfonat dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.72 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-hidroksietilfosfonat dioksigenaza (EC 1.13.11.72, HEPD, phpD (gen)) je enzim sa sistematskim imenom 2-hidroksietilfosfonat:O2 1,2-oksidoreduktaza (formira hidroksimetilfosfonat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-hidroksietilfosfonat + O2 hidroksimetilfosfonat + format
Ovaj enzim sadrži Fe(II) koje nije vezano za hem. Izolovan je iz više bakterijskih vrsta, uključujući Streptomyces hygroscopicus i Streptomyces viridochromogenes.
Reference[uredi | uredi kod]
- ↑ Cicchillo, R.M., Zhang, H., Blodgett, J.A., Whitteck, J.T., Li, G., Nair, S.K., van der Donk, W.A. and Metcalf, W.W. (2009). „An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis”. Nature 459: 871-874. PMID 19516340.
- ↑ Whitteck, J.T., Malova, P., Peck, S.C., Cicchillo, R.M., Hammerschmidt, F. and van der Donk, W.A. (2011). „On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase”. J. Am. Chem. Soc. 133: 4236-4239. PMID 21381767.
- ↑ Peck, S.C., Cooke, H.A., Cicchillo, R.M., Malova, P., Hammerschmidt, F., Nair, S.K. and van der Donk, W.A. (2011). „Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase”. Biochemistry 50: 6598-6605. PMID 21711001.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.