2-Dezoksistreptamin N-acetil-D-glukozaminiltransferaza
(Preusmjereno sa stranice 2-dezoksistreptamin N-acetil-D-glukozaminiltransferaza)
| 2-Dezoksistreptamin N-acetil-D-glukozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.283 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Dezoksistreptamin N-acetil-D-glukozaminiltransferaza (EC 2.4.1.283, btrM (gen), neoD (gen), kanF (gen)) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin:2-dezoksistreptamin N-acetil-D-glukozaminiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-alfa-D-glukozamin + 2-dezoksistreptamin UDP + 2'-N-acetilparomamin
Ovaj enzim učestvuje u biosintezi nekoliko klinički značajnih aminociklitolnih antibiotika, uključujući kanamicin, butirozin, neomicin i ribostamicin.
Reference[uredi | uredi kod]
- ↑ Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. (2008). „Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis”. ChemBioChem. 9: 865-869. PMID 18311744.
- ↑ Park, J.W., Park, S.R., Nepal, K.K., Han, A.R., Ban, Y.H., Yoo, Y.J., Kim, E.J., Kim, E.M., Kim, D., Sohng, J.K. and Yoon, Y.J. (2011). „Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation”. Nat. Chem. Biol. 7: 843-852. PMID 21983602.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.