2-dezoksi-scilo-inozamin dehidrogenaza
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| 2-dezoksi-scilo-inozamin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.329 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2-dezoksi-scilo-inozamin dehidrogenaza (EC 1.1.1.329, neoA (gen), kanK (gen)) je enzim sa sistematskim imenom 2-dezoksi-scilo-inozamin:NAD(P)+ 1-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2-dezoksi-scilo-inozamin + NAD(P)+ 3-amino-2,3-didezoksi-scilo-inozoza + NAD(P)H + H+
Za rad ovog enzima je neophodan cink. 2-dezoksi-scilo-inozamin dehidrogenaza učestvuje u biosintetičkim putevima nekoliko klinički značajnih aminociklitolnih antibiotika, uključujući kanamicin, neomicin i ribostamicin, cf. EC 1.1.99.38, 2-dezoksi-scilo-inozamin dehidrogenaza (SAM-zavisna).
Reference[uredi | uredi kod]
- ↑ Kudo, F., Yamamoto, Y., Yokoyama, K., Eguchi, T. and Kakinuma, K. (2005). „Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773”. J. Antibiot. (Tokyo) 58: 766-774. PMID 16506694.
- ↑ Nepal, K.K., Oh, T.J. and Sohng, J.K. (2009). „Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853”. Mol. Cells 27: 601-608. PMID 19466609.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.