2-Metilcitratna dehidrataza
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| 2-Metilcitratna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.79 | ||||||||
| CAS broj | 80891-26-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2-Metilcitratna dehidrataza (EC 4.2.1.79, 2-metilcitratna hidrolijaza, PrpD, 2-hidroksibutan-1,2,3-trikarboksilatna hidrolijaza) je enzim sa sistematskim imenom (2S,3S)-2-hidroksibutan-1,2,3-trikarboksilat hidrolijaza (formira (Z)-but-2-en-1,2,3-trikarboksilat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2S,3S)-2-hidroksibutan-1,2,3-trikarboksilat (Z)-but-2-en-1,2,3-trikarboksilat + H2O
Ovaj enzim je specifičan za (2S,3S)-metilcitrat.
Reference[uredi | uredi kod]
- ↑ Aoki, H. and Tabuchi, T. (1981). „Purification and properties of 2-methylcitrate dehydratase from Yarrowia lipolytica”. Agric. Biol. Chem. 45: 2831-2837.
- ↑ Brock, M., Maerker, C., Schütz, A., Völker, U. and Buckel, W. (2002). „Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase”. Eur. J. Biochem. 269: 6184-6194. PMID 12473114.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.