2-Iminoacetatna sintaza
Prijeđi na navigaciju
Prijeđi na pretragu
| 2-Iminoacetatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.99.19 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Iminoacetatna sintaza (EC 4.1.99.19, thiH (gen)) je enzim sa sistematskim imenom L-tirozin 4-metilfenol-lijaza (formira 2-iminoacetat).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-tirozin + S-adenozil-L-metionin + redukovani akceptor 2-iminoacetat + 4-metilfenol + 5'-dezoksiadenozin + L-metionin + akceptor + 2 H+
Ovaj enzim sadrži 4Fe-4S kluster.
Reference[uredi | uredi kod]
- ↑ Leonardi, R., Fairhurst, S.A., Kriek, M., Lowe, D.J. and Roach, P.L. (2003). „Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex”. FEBS Lett. 539: 95-99. PMID 12650933.
- ↑ Kriek, M., Martins, F., Challand, M.R., Croft, A. and Roach, P.L. (2007). „Thiamine biosynthesis in Escherichia coli: identification of the intermediate and by-product derived from tyrosine”. Angew. Chem. Int. Ed. Engl. 46: 9223-9226. PMID 17969213.
- ↑ Kriek, M., Martins, F., Leonardi, R., Fairhurst, S.A., Lowe, D.J. and Roach, P.L. (2007). „Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro”. J. Biol. Chem. 282: 17413-17423. PMID 17403671.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.