2-Hidroksiheksa-2,4-dienoatna hidrataza
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| 2-Hidroksiheksa-2,4-dienoatna hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.132 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
2-Hidroksiheksa-2,4-dienoatna hidrataza (EC 4.2.1.132, tesE (gen), hsaE (gen)) je enzim sa sistematskim imenom 4-hidroksi-2-oksoheksanoat hidrolijaza (formira (2Z,4Z)-2-hidroksiheksa-2,4-dienoat).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-hidroksi-2-oksoheksanoat (2Z,4Z)-2-hidroksiheksa-2,4-dienoat + H2O
Ovaj enzim katalizuje jedan od kasnijih koraka bakterijske degradacije steroida.
Reference[uredi | uredi kod]
- ↑ Horinouchi, M., Hayashi, T., Koshino, H., Kurita, T. and Kudo, T. (2005). „Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441”. Appl. Environ. Microbiol. 71: 5275-5281. PMID 16151114.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.