2-Fosfo-L-laktat transferaza
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| 2-Fosfo-L-laktat transferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.8.28 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2-Fosfo-L-laktat transferaza (EC 2.7.8.28, LPPG:Fo 2-fosfo-L-laktat transferaza, LPPG:7,8-didemetil-8-hidroksi-5-deazariboflavin 2-fosfo-L-laktat transferaza, MJ1256, laktil-2-difosfo-(5')guanozin:Fo 2-fosfo-L-laktat transferaza, CofD) je enzim sa sistematskim imenom (2S)-laktil-2-difosfo-5'-guanozin:7,8-didemetil-8-hidroksi-5-deazariboflavin 2-fosfo-L-laktat transferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2S)-laktil-2-difosfo-5'-guanozin + 7,8-didemetil-8-hidroksi-5-deazariboflavin GMP + koenzim F420-0
Ovaj enzim učestvuje u biosintezi koenzima F420.
Reference[uredi | uredi kod]
- ↑ Graupner, M., Xu, H. and White, R.H. (2002). „Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F420 biosynthesis in Methanococcus jannaschii”. Biochemistry 41: 3754-3761. PMID 11888293.
- ↑ Forouhar, F., Abashidze, M., Xu, H., Grochowski, L.L., Seetharaman, J., Hussain, M., Kuzin, A., Chen, Y., Zhou, W., Xiao, R., Acton, T.B., Montelione, G.T., Galinier, A., White, R.H. and Tong, L. (2008). „Molecular insights into the biosynthesis of the F420 coenzyme”. J. Biol. Chem. 283: 11832-11840. PMID 18252724.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.