2-Amino-3,7-didezoksi-D-treo-hept-6-ulosonat sintaza
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| 2-Amino-3,7-didezoksi-D-treo-hept-6-ulosonat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.2.1.10 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2-Amino-3,7-didezoksi-D-treo-hept-6-ulosonat sintaza (EC 2.2.1.10, ADH sintaza, ADHS, MJ0400 (gen)) je enzim sa sistematskim imenom L-aspartat 4-semialdehid:1-dezoksi-D-treo-hekso-2,5-diuloza 6-fosfat metilglioksaltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-aspartat 4-semialdehid + 1-dezoksi-D-treo-hekso-2,5-diuloza 6-fosfat 2-amino-3,7-didezoksi-D-treo-hept-6-ulosonat + 2,3-dioksopropil fosfat
Ovaj enzim ima ključnu ulogu u alternativnoj biosintezi 3-dehidrohinata (DHQ), koji učestvuje u kanoničkoj biosintezi aromatičnnih aminokiselina.
Reference[uredi | uredi kod]
- ↑ White, R.H. (2004). „L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii”. Biochemistry 43: 7618-7627. PMID 15182204.
- ↑ Samland, A.K., Wang, M. and Sprenger, G.A. (2008). „MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity”. FEMS Microbiol. Lett. 281: 36-41. PMID 18318840.
- ↑ Morar, M., White, R.H. and Ealick, S.E. (2007). „Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids”. Biochemistry 46: 10562-10571. PMID 17713928.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.