12-O-Tetradekanoilforbol-13-acetat

Izvor: Wikipedia
12-O-Tetradekanoilforbol-13-acetat
TPA
IUPAC ime
Drugi nazivi TPA, PMA, Forbol miristat acetat,
Tetradekanoilforbol acetat.
Identifikacija
CAS registarski broj 16561-29-8 YesY
PubChem[1][2] 10475874
ChemSpider[3] 17215855 YesY
KEGG[4] C05151
ChEMBL[5] CHEMBL279115 YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C36H56O8
Molarna masa 616.83 g mol−1

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

12-O-tetradekanoilforbol-13-acetat (TPA) (tetradekanoilforbol acetat, tetradekanoil forbol acetat, forbol 12-miristat 13-acetat, PMA) je diestar forbola i potentan promoter tumora koji se često koristi u biomedicinskim istraživanjima za aktiviranje prenosa signala enzima proteinska kinaza C (PKC).[6][7][8] TPA deluje na PKC usled njegove sličnosti sa prirodnim aktivatorom klasičnih PKC izoformi, diacilglicerolom.

TPA se istražuje kao potencijalni lek za tretman hematološkog kancera.

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  6. Castagna et al. (1982). "Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters". Journal of Biological Chemistry 257 (13): 7847–7851. 
  7. Blumberg (1988). "Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture". Cancer Research 48: 1–8. 
  8. Niedel et al. (1983). "Phorbol Diester Receptor Copurifies with Protein Kinase C". Proceedings of the National Academy of Sciences 80: 36–40. doi:10.1073/pnas.80.1.36. 

Spoljašnje veze[uredi - уреди]