1-Fosfatidilinozitol-4-fosfat 5-kinaza
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| 1-Fosfatidilinozitol-4-fosfat 5-kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.68 | ||||||||
| CAS broj | 104645-76-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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1-Fosfatidilinozitol-4-fosfat 5-kinaza (EC 2.7.1.68, difosfoinozitidna kinaza, PIP kinaza, fosfatidilinozitol 4-fosfatna kinaza, fosfatidilinozitol-4-fosfatna 5-kinaza, tip I PIP kinaza) je enzim sa sistematskim imenom ATP:1-fosfatidil-1D-mio-inozitol-4-fosfat 5-fosfotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim takođe fosforiliše PtdIns3P u 4-poziciji, i PtdIns, PtdIns3P i PtdIns(3,4)P2 u 5-pozicija in vitro.
Reference[uredi | uredi kod]
- ↑ Kai, M., Salway, J.G. and Hawthorne, J.N. (1968). „The diphosphoinositide kinase of rat brain”. Biochem. J. 106: 791-801. PMID 4295336.
- ↑ Kai, M., Salway, J.G., Michell, R.H. and Hawthorne, J.N. (1966). „The biosynthesis of triphosphoinositide by rat brain in vitro”. Biochem. Biophys. Res. Commun. 22: 370-375.
- ↑ Rameh, L.E., Tolias, K.F., Duckworth, B.C. and Cantley, L.C. (1997). „A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate”. Nature 390: 192-196. PMID 9367159.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.