1,8-Cineol 2-ekso-monooksigenaza
(Preusmjereno sa stranice 1,8-cineol 2-ekso-monooksigenaza)
| 1,8-Cineol 2-ekso-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.157 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
1,8-Cineol 2-ekso-monooksigenaza (EC 1.14.13.157, CYP3A4) je enzim sa sistematskim imenom 1,8-cineol,NADPH:kiseonik oksidoreduktaza (2-ekso-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1,8-cineol + NADPH + H+ + O2 2-ekso-hidroksi-1,8-cineol + NADP+ + H2O
Ovaj enzim je hem-tiolatni protein (P-450). Enzim sisara koji je izražen u jetrenim mikrozomima deluje na više strukturno različitih jedinjenja, uključujući steroide, masne kiseline, i ksenobiotike.
Reference[uredi | uredi kod]
- ↑ Miyazawa, M., Shindo, M. and Shimada, T. (2001). „Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from Eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes”. Drug Metab. Dispos. 29: 200-205. PMID 11159812.
- ↑ Miyazawa, M. and Shindo, M. (2001). „Biotransformation of 1,8-cineole by human liver microsomes”. Nat. Prod. Lett. 15: 49-53. PMID 11547423.
- ↑ Miyazawa, M., Shindo, M. and Shimada, T. (2001). „Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes”. Xenobiotica 31: 713-723. PMID 11695850.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.