1,4-Dihidroksi-2-naftoil-KoA hidrolaza
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| 1,4-dihidroksi-2-naftoil-KoA hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.2.28 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
1,4-dihidroksi-2-naftoil-KoA hidrolaza (EC 3.1.2.28) je enzim sa sistematskim imenom 1,4-dihidroksi-2-naftoil-KoA hidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1,4-dihidroksi-2-naftoil-KoA + H2O 1,4-dihidroksi-2-naftoat + KoA
Ovaj enzim učestvuje u sintezi menahinona, filohinona, kao i nekoliko biljnih pigmenata.
Reference[uredi | uredi kod]
- ↑ Widhalm, J.R., van Oostende, C., Furt, F. and Basset, G.J. (2009). „A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1”. Proc. Natl. Acad. Sci. USA 106: 5599-5603. PMID 19321747.
- ↑ Muller, W and Leistner, E (1976). „1,4-naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis”. Phytochemistry 15: 407-410.
- ↑ Eichinger D, Bacher A., Zenk M.H. and Eisenreich W. (1999). „Quantitative assessment of metabolic flux by 13C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum”. J. Am. Chem. Soc. 121: 7469-7475.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.