(S)-mandelat dehidrogenaza
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| (S)-mandelat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.99.31 | ||||||||
| CAS broj | 9067-95-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(S)-mandelat dehidrogenaza (EC 1.1.99.31, MDH) je enzim sa sistematskim imenom (S)-mandelat:akceptor 2-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (S)-mandelat + akceptor fenilglioksilat + redukovani akceptor
Ovaj enzim je član FMN zavisne familije oksidaza/dehidrogenaza alfa-hidroksi-kiselina. Svi enzimi ove familije oksidišu (S)-enantiomer alfa-hidroksi kiselina do alfa-okso kiselina. Izvor oksidansa (kiseonik, intramolekulski hem ili neki drugi akceptor) je zavistan od specifičnog enzima.
Reference[uredi | uredi kod]
- ↑ Lehoux, I.E. and Mitra, B. (1999). „(S)-Mandelate dehydrogenase from Pseudomonas putida: mechanistic studies with alternate substrates and pH and kinetic isotope effects”. Biochemistry 38: 5836-5848. PMID 10231535.
- ↑ Dewanti, A.R., Xu, Y. and Mitra, B. (2004). „Role of glycine 81 in (S)-mandelate dehydrogenase from Pseudomonas putida in substrate specificity and oxidase activity”. Biochemistry 43: 10692-10700. PMID 15311930.
- ↑ Dewanti, A.R., Xu, Y. and Mitra, B. (2004). „Esters of mandelic acid as substrates for (S)-mandelate dehydrogenase from Pseudomonas putida: implications for the reaction mechanism”. Biochemistry 43: 1883-1890. PMID 14967029.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.