(R)-benzilsukcinil-KoA dehidrogenaza
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| (R)-benzilsukcinil-KoA dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.8.3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(R)-benzilsukcinil-KoA dehidrogenaza (EC 1.3.8.3, BbsG, (R)-benzilsukcinil-KoA:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom (R)-benzilsukcinil-KoA:elektron transfer flavoprotein oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (R)-2-benzilsukcinil-KoA + elektron-transfer flavoprotein (E)-2-benzilidensukcinil-KoA + redukovani elektron-transfer flavoprotein
Ovaj enzim koristi FAD kao prostetičku grupu. Ta razliku od acil-KoA dehidrogenaza, ovaj enzim manifestuje visoku supstratnu i enantiomernu specifičnost. On je visoko specifičan za (R)-benzilsukcinil-KoA, a inhibira ga (S)-benzilsukcinil-KoA.
Reference[uredi | uredi kod]
- ↑ Leutwein, C. and Heider, J. (1999). „Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and β-oxidation of the first intermediate, (R)-(+)-benzylsuccinate”. Microbiology 145: 3265-3271. PMID 10589736.
- ↑ Leutwein, C. and Heider, J. (2002). „(R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway”. Arch. Microbiol. 178: 517-524. PMID 12420174.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.