(-)-Germakrenska D sintaza

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(-)-Germakrenska D sintaza
Identifikatori
EC broj 4.2.3.75
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

(-)-Germakrenska D sintaza (EC 4.2.3.75, (-)-germacrene D synthase) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (-)-germakren-D).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(2E,6E)-farnezil difosfat \rightleftharpoons (-)-germakren D + difosfat

U Solidago canadensis ova biosinteza proizvodi pro-R vodonik u C-1 farnezil difosfata.

Reference[uredi - уреди]

  1. Schmidt, C.O., Bouwmeester, H.J., Franke, S. and König, W.A. (1999). "Mechanisms of the biosynthesis of sesquiterpene enantiomers (+)- and (-)-germacrene D in Solidago canadensis". Chirality 11: 353–362. 
  2. He, X. and Cane, D.E. (2004). "Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2)". J. Am. Chem. Soc. 126: 2678–2679. PMID 14995166. 
  3. Lucker, J., Bowen, P. and Bohlmann, J. (2004). "Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries". Phytochemistry 65: 2649–2659. PMID 15464152. 
  4. Prosser, I., Altug, I.G., Phillips, A.L., Konig, W.A., Bouwmeester, H.J. and Beale, M.H. (2004). "Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif". Arch. Biochem. Biophys. 432: 136–144. PMID 15542052. 

Literatura[uredi - уреди]

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