Bornil difosfatna sintaza

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Bornil difosfatna sintaza
Identifikatori
EC broj 5.5.1.8
CAS broj 72668-91-8
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Bornil difosfatna sintaza (EC 5.5.1.8, bornil pirofosfatna sintaza, bornil pirofosfatna sintetaza, (+)-bornilpirofosfatna ciklaza, geranil-difosfatna ciklaza) je enzim sa sistematskim imenom (+)-bornil-difosfat lijaza (deciklizacija).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

geranil difosfat (+)-bornil difosfat

Za dejstvo ovog enzima je neophodan jon Mn2+.

Reference[uredi | uredi kod]

  1. Croteau, R. and Karp, F. (1979). „Biosynthesis of monoterpenes: preliminary characterization of bornyl pyrophosphate synthetase from sage (Salvia officinalis) and demonstration that geranyl pyrophosphate is the preferred substrate for cyclization”. Arch. Biochem. Biophys. 198: 512-522. PMID 42356. 
  2. Croteau, R., Gershenzon, J., Wheeler, C.J. and Satterwhite, D.M. (1990). „Biosynthesis of monoterpenes: stereochemistry of the coupled isomerization and cyclization of geranyl pyrophosphate to camphane and isocamphane monoterpenes”. Arch. Biochem. Biophys. 277: 374-381. PMID 2178556. 
  3. Croteau, R., Satterwhite, D.M., Cane, D.E. and Chang, C.C. (1986). „Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-bornyl pyrophosphate”. J. Biol. Chem. 261: 13438-13445. PMID 3759972. 
  4. Croteau, R., Felton, N.M. and Wheeler, C.J. (1985). „Stereochemistry at C-1 of geranyl pyrophosphate and neryl pyrophosphate in the cyclization to (+)- and (-)-bornyl pyrophosphate”. J. Biol. Chem. 260: 5956-5962. PMID 3997807. 
  5. Croteau, R.B., Shaskus, J.J., Renstrom, B., Felton, N.M., Cane, D.E., Saito, A. and Chang, C. (1985). „Mechanism of the pyrophosphate migration in the enzymatic cyclization of geranyl and linalyl pyrophosphates to (+)- and (-)-bornyl pyrophosphates”. Biochemistry 24: 7077-7085. PMID 4084562. 
  6. McGeady, P. and Croteau, R. (1995). „Isolation and characterization of an active-site peptide from a monoterpene cyclase labeled with a mechanism-based inhibitor”. Arch. Biochem. Biophys. 317: 149-155. PMID 7872777. 
  7. Wise, M.L., Savage, T.J., Katahira, E. and Croteau, R. (1998). „Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase”. J. Biol. Chem. 273: 14891-14899. PMID 9614092. 
  8. Whittington, D.A., Wise, M.L., Urbansky, M., Coates, R.M., Croteau, R.B. and Christianson, D.W. (2002). „Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase”. Proc. Natl. Acad. Sci. USA 99: 15375-15380. PMID 12432096. 
  9. Peters, R.J. and Croteau, R.B. (2003). „Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases”. Arch. Biochem. Biophys. 417: 203-211. PMID 12941302. 

Literatura[uredi | uredi kod]

Vanjske veze[uredi | uredi kod]