Aktivator faktora V zmijskog venuma
(Preusmjereno sa stranice Zmijski venum faktor V activator)
Aktivator faktora V zmijskog venuma | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.21.95 | ||||||||
CAS broj | 123757-15-3, 123757-16-4, 123757-17-5, 123757-18-6&title= 471269-12-2, 123757-15-3, 123757-16-4, 123757-17-5, 123757-18-6 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Aktivator faktora V zmijskog venuma (EC 3.4.21.95, Snake venom factor V activator) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Potpuna aktivacija ljudskog faktora zgrušavanja V jednim presecanjem Trp-Tyr-Leu-Arg1545-Ser-Asn-Asn--Gly veze. Goveđi, ali ne i zečji, faktor V se preseca, i ne dolazi do reakcije na drugim proteinima sistema zgrušavanja. Esterazna aktivnost je primećena na Bz-Arg-OEt i Tos-Arg-OMe, i amidazna na Phe-pipekolil-Arg-NHPhNO2
Ovaj enzim je izolovan iz venuma Vipera russelli.
- ↑ Kisiel, W. and Canfield, W. (1981). „M. Snake venom proteases that activate blood-coagulation factor V”. Methods Enzymol. 80: 275-285. PMID 7043192.
- ↑ Tokunaga, F., Nagasawa, K., Tamura, S., Miyata, T., Iwanaga, S. and Kisiel, W. (1988). „The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-Vα, -Vβ and -Vγ and their complete amino acid sequences”. J. Biol. Chem. 263: 17417-17481. PMID 3053712.
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