8-Hidroksifuranokumarin 8-O-metiltransferaza
8-hidroksifuranokumarin 8-O-metiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.1.1.70 | ||||||||
CAS broj | 67339-13-3 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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8-hidroksifuranokumarin 8-O-metiltransferaza (EC 2.1.1.70, furanokumarinska 8-metiltransferaza, furanokumarinska 8-O-metil-transferaza, ksantotoksolna 8-O-metiltransferaza, XMT, 8-hidroksifuranokumarinska 8-O-metiltransferaza, SAM:ksantotoksol O-metiltransferaza, S-adenozil-L-metionin:8-hidroksifuranokumarin 8-O-metiltransferaza, ksantotoksolna metiltransferaza, ksantotoksolna O-metiltransferaza, S-adenozil-L-metionin:ksantotoksol O-metiltransferaza, S-adenozil-L-metionin-ksantotoksolna O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:8-hidroksifurokumarin 8-O-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) S-adenozil-L-metionin + 8-hidroksifurokumarin S-adenozil-L-homocistein + 8-metoksifurokumarin (opšta reakcija)
- (2) S-adenozil-L-metionin + ksantotoksol S-adenozil-L-homocistein + ksantotoksin
Enzim konvertuje ksantotoksol u ksantotoksin, koji ima terapeutski potencijal u treatmanu psorijaze.
- ↑ Thompson, H.J., Sharma, S.K. and Brown, S.A. (1978). „O-Methyltransferases of furanocoumarin biosynthesis”. Arch. Biochem. Biophys. 188: 272-281. PMID 28084.
- ↑ Hauffe, K.D., Hahlbrock, K. and Scheel, D. (1986). „Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases”. Z. Naturforsch. C: Biosci. 41: 228-239.
- ↑ Sharma, S.K., Garrett, J.M. and Brown, S.A. (1979). „Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography”. Z. Naturforsch. [C] 34C: 387-391. PMID 156999.
- ↑ Hehmann, M., Lukačin, R., Ekiert, H. and Matern, U. (2004). „Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase”. Eur. J. Biochem. 271: 932-940. PMID 15009205.
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