23S rRNK (guanin745-N1)-metiltransferaza
(Preusmjereno sa stranice RRNA(m1G)methylase)
23S rRNK (guanin745-N1)-metiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.1.1.187 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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23S rRNK (guanin745-N1)-metiltransferaza (EC 2.1.1.187, Rlma(I), Rlma1, 23S rRNK m1G745 metiltransferaza, YebH, RlmAI metiltransferaza, ribozomalna RNK(m1G)-metilaza (nespecifična), rRNK(m1G)metilaza (nespecifična), RrmA (nespecifična), 23S rRNK:m1G745 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanin745-N1)-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanin745 u 23S rRNK S-adenozil-L-homocistein + N1-metilguanin745 u 23S rRNK
Ovaj enzim specifično metiliše guanin745 u N1 poziciji 23S rRNK.
- ↑ Liu, M., Novotny, G.W. and Douthwaite, S. (2004). „Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase”. RNA 10: 1713-1720. PMID 15388872.
- ↑ Gustafsson, C. and Persson, B.C. (1998). „Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant”. J. Bacteriol. 180: 359-365. PMID 9440525.
- ↑ Das, K., Acton, T., Chiang, Y., Shih, L., Arnold, E. and Montelione, G.T. (2004). „Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site”. Proc. Natl. Acad. Sci. USA 101: 4041-4046. PMID 14999102.
- ↑ Hansen, L.H., Kirpekar, F. and Douthwaite, S. (2001). „Recognition of nucleotide G745 in 23 S ribosomal RNA by the rrmA methyltransferase”. J. Mol. Biol. 310: 1001-1010. PMID 11501991.
- ↑ Liu, M. and Douthwaite, S. (2002). „Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria”. Mol. Microbiol. 44: 195-204. PMID 11967079.
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