Kjuin tRNK-riboziltransferaza
(Preusmjereno sa stranice Q-insertase)
Kjuin tRNK-riboziltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.4.2.29 | ||||||||
CAS broj | 72162-89-1 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Kjuin tRNK-riboziltransferaza (EC 2.4.2.29, enzim umetanja kjuina, tRNK transglikozilaza, Q-insertaza, kjuin34 transfer ribonukleatna riboziltransferaza, transfer ribonukleatna glikoziltransferaza, tRNK kjuin34 transglikosidaza, kjuinska tRNK-riboziltransferaza, TGT, (tRNK)-kjuin34:kjuin tRNK-D-riboziltransferaza, transfer ribonukleinska kiselina kjuin34 transglikozilaza) je enzim sa sistematskim imenom tRNK-guanozin34:kjuin tRNK-D-riboziltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) guanin34 u tRNK + kveuin kveuin34 u tRNK + guanin
- (2) guanin34 u tRNK + 7-aminometil-7-karbaguanin 7-aminometil-7-karbaguanin34 u tRNK + guanin
Pojedine prokariotske i eukariotske tRNK sadrže modifikovanu bazu kjuin u poziciji 34.
- ↑ Howes, N.K. and Farkas, W.R. (1978). „Studies with a homogeneous enzyme from rabbit erythrocytes catalyzing the insertion of guanine into tRNA”. J. Biol. Chem. 253: 9082-9087. PMID 721832.
- ↑ Okada, N., Noguchi, S., Kasai, H., Shindo-Okada, N., Ohgi, T., Goto, T. and Nishimura, S. (1979). „Novel mechanism of post-transcriptional modification of tRNA. Insertion of bases of Q precursors into tRNA by a specific tRNA transglycosylase reaction”. J. Biol. Chem. 254: 3067-3073. PMID 372186.
- ↑ Shindo-Okada, N., Okada, N., Ohgi, T., Goto, T. and Nishimura, S. (1980). „Transfer ribonucleic acid guanine transglycosylase isolated from rat liver”. Biochemistry 19: 395-400. PMID 6986171.
- ↑ Todorov, K.A. and Garcia, G.A. (2006). „Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity”. Biochemistry 45: 617-625. PMID 16401090.
- ↑ Boland, C., Hayes, P., Santa-Maria, I., Nishimura, S. and Kelly, V.P. (2009). „Queuosine formation in eukaryotic tRNA occurs via a mitochondria-localized heteromeric transglycosylase”. J. Biol. Chem. 284: 18218-18227. PMID 19414587.
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