Pseudolizin
(Preusmjereno sa stranice Pseudomonas elastaza)
Pseudolizin | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.24.26 | ||||||||
CAS broj | 171715-23-4 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Pseudolizin (EC 3.4.24.26, Pseudomonas elastaza, Pseudomonas aeruginosa neutralna metaloproteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina uključujući elastin, kolagen tipa III i IV, fibronektin i imunoglobulin A, generalno sa glomaznim hidrofobnim grupama u P1'. Lanac insulina B se razlaže na identičnom šablonu prepoznavanja sa termolizinom, ali postoje razlike u specifinosti u drugim pogledima
Ovaj enzim pripada peptidaznoj familiji M4 (termolizinskoj familiji).
- ↑ Morihara, K. and Tsuzuki, H. (1975). „Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase”. Agric. Biol. Chem. 39: 1123-1128.
- ↑ Nishino, N. and Powers, J.C. (1980). „Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand”. J. Biol. Chem. 255: 3482-3486. PMID 6767718.
- ↑ Dreyfus, L.A. and Iglewski, B.H. (1986). „Purification and characterization of an extracellular protease of Legionella pneumophila”. Infect. Immun. 70: 736-743. PMID 3512431.
- ↑ Bever, R.A. and Iglewski, B.H. (1988). „Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene”. J. Bacteriol. 170: 4309-4314. PMID 2842313.
- ↑ Black, W.J., Quinn, F.D. and Tompkins, L.S. (1990). „Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase”. J. Bacteriol. 172: 2608-2613. PMID 2110146.
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