Plazmepsin I
(Preusmjereno sa stranice PFAPG)
Plazmepsin I | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.23.38 | ||||||||
CAS broj | 180189-87-1 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Plazmepsin I (EC 3.4.23.38, aspartinska hemoglobinaza I, PFAPG, malarijska aspartinska hemoglobinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza -Phe33-Leu- veze u alfa-lancu hemoglobina, što dovodi do denaturacije molekula
Ovaj enzim je pristan u malarijskom organizmu, Plasmodium.
- ↑ Goldberg, D.E., Slater, A.F.G., Beavis, R., Chait, B., Cerami, A. and Henderson, G.B. (1991). „Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease”. J. Exp. Med. 173: 961-969. PMID 2007860.
- ↑ Francis, S.E., Gluzman, I.Y., Oksman, A., Knickerbocker, A., Mueller, R., Bryant, M.L., Sherman, D.R., Russell, D.G. and Goldberg, D.E. (1994). „Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase”. EMBO J. 13: 306-317. PMID 8313875.
- ↑ Gluzman, I.Y., Francis, S.E., Oksman, A., Smith, C.E., Duffin, K.L. and Goldberg, D.E. (1994). „Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway”. J. Clin. Invest. 93: 1602-1608. PMID 8163662.
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
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