O-fosfo-L-seril-tRNK:Cys-tRNK sintaza
(Preusmjereno sa stranice O-fosfo-L-seril-tRNK:Cys-tRNK-sintaza)
O-fosfo-L-seril-tRNK:Cys-tRNK sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.5.1.73 | ||||||||
CAS broj | 1239229-21-0 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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O-fosfo-L-seril-tRNK:Cys-tRNK sintaza (EC 2.5.1.73, SepCysS, Sep-tRNK:Cys-tRNK sintaza) je enzim sa sistematskim imenom O-fosfo-L-seril-tRNKCis:vodonik sulfid 2-aminopropanoat transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
U organizmima poput Archaeoglobus fulgidus kojima nedostaje enzim EC 6.1.1.16 (cistein---tRNK ligaza) za direktno formiranje Cys-tRNKCys, taj molekul se indirektno obrazuje posredstvom enzima EC 6.1.1.27 (O-fosfoseril-tRNK ligaze) koja ligira O-fosfoserin do tRNKCys, i EC 2.5.1.73, koji konvertuje nastali O-fosfo-L-seril-tRNKCys do Cys-tRNKCys.
- ↑ Fukunaga, R. and Yokoyama, S. (2007). „Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus”. J. Mol. Biol. 370: 128-141. PMID 17512006.
- ↑ Hauenstein, S.I. and Perona, J.J. (2008). „Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei”. J. Biol. Chem. 283: 22007-22017. PMID 18559341.
- ↑ Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). „RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea”. Proc. Natl. Acad. Sci. USA 103: 18923-18927. PMID 17142313.
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