Protein N-terminal metiltransferaza
(Preusmjereno sa stranice NMT1 (gene name))
Protein N-terminal metiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.1.1.244 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Protein N-terminal metiltransferaza (EC 2.1.1.244, NMT1 (gen), METTL11A (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:N-terminal-(A,P,S)PK-(protein) metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 3 S-adenozil-L-metionin + N-terminal-(A,S)PK-[protein] 3 S-adenozil-L-homocistein + N-terminal-N,N,N-trimetil-N-(A,S)PK-[protein] (sveukupna reakcija)
- (1a) S-adenozil-L-metionin + N-terminal-(A,S)PK-[protein] S-adenozil-L-homocistein + N-terminal-N-metil-N-(A,S)PK-[protein]
- (1b) S-adenozil-L-metionin + N-terminal-N-metil-N-(A,S)PK-[protein] S-adenozil-L-homocistein + N-terminal-N,N-dimetil-N-(A,S)PK-[protein]
- (1c) S-adenozil-L-metionin + N-terminaL-N,N-dimetil-N-(A,S)PK-serin-[protein] S-adenozil-L-homocistein + N-terminal-N,N,N-trimetil-N-(A,S)PK-[protein]
- (2) 2 S-adenozil-L-metionin + N-terminal-PPK-[protein] 2 S-adenozil-L-homocistein + N-terminal-N,N-dimetil-N-PPK-[protein] (sveukupna reakcija)
- (2a) S-adenozil-L-metionin + N-terminal-PPK-[protein] S-adenozil-L-homocistein + N-terminal-N-metil-N-PPK-[protein]
- (2b) S-adenozil-L-metionin + N-terminal-N-metil-N-PPK-[protein] S-adenozil-L-homocistein + N-terminal-N,N-dimetil-N-PPK-[protein]
Ovaj enzim metiliše N-terminus ciljnih proteina koji sadrže N-terminalni motiv [Ala/Pro/Ser]-Pro-Lys nakon odsecanja inicijatora L-metionina. Kad je terminalna aminokiselina L-prolin, ovaj enzim katalizuje dve uzastopne metilacije alfa-amino grupa.
- ↑ Webb, K.J., Lipson, R.S., Al-Hadid, Q., Whitelegge, J.P. and Clarke, S.G. (2010). „Identification of protein N-terminal methyltransferases in yeast and humans”. Biochemistry 49: 5225-5235. PMID 20481588.
- ↑ Tooley, C.E., Petkowski, J.J., Muratore-Schroeder, T.L., Balsbaugh, J.L., Shabanowitz, J., Sabat, M., Minor, W., Hunt, D.F. and Macara, I.G. (2010). „NRMT is an α-N-methyltransferase that methylates RCC1 and retinoblastoma protein”. Nature 466: 1125-1128. PMID 20668449.
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