B-adrenergički-receptor kinaza
(Preusmjereno sa stranice GRK3)
B-adrenergički-receptor kinaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.7.11.15 | ||||||||
CAS broj | 102925-39-3 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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B-adrenergički-receptor kinaza (EC 2.7.11.15, ATP:beta-adrenergički-receptor fosfotransferaza, beta-adrenergički receptor-specifična kinaza, beta-AR kinaza, beta-ARK, beta-ARK 1, beta-ARK 2, beta-receptor kinaza, GRK2, GRK3, beta-adrenergički-receptor kinaza (fosforilacija), beta2ARK, betaARK1, beta-adrenoceptor kinaza, beta-adrenoceptor kinaza 1, beta-adrenoceptor kinaza 2, ADRBK1, BARK1, adrenergički receptor kinaza, STK15) je enzim sa sistematskim imenom ATP:(beta-adrenergic receptor) fosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
G-protein je neophodan za aktivaciju i stoga ovaj enzim pripada familiji G-protein-zavisnih receptorskih kinaza (GRKs).
- ↑ Benovic, J.L., Mayor, F., Jr., Staniszewski, C., Lefkowitz, R.J. and Caron, M.G. (1987). „Purification and characterization of the β-adrenergic receptor kinase”. J. Biol. Chem. 262: 9026-9032. PMID 3036840.
- ↑ Kim, C.M., Dion, S.B., Onorato, J.J. and Benovic, J.L. (1993). „Expression and characterization of two β-adrenergic receptor kinase isoforms using the baculovirus expression system”. Receptor 3: 39-55. PMID 8394172.
- ↑ Laugwitz, K.L., Kronsbein, K., Schmitt, M., Hoffmann, K., Seyfarth, M., Schomig, A. and Ungerer, M. (1997). „Characterization and inhibition of β-adrenergic receptor kinase in intact myocytes”. Cardiovasc Res 35: 324-333. PMID 9349395.
- ↑ Ferguson, S.S., Menard, L., Barak, L.S., Koch, W.J., Colapietro, A.M. and Caron, M.G. (1995). „Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by betaARK1”. J. Biol. Chem. 270: 24782-24789. PMID 7559596.
- ↑ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). „Non-visual GRKs: are we seeing the whole picture?”. Trends Pharmacol. Sci. 24: 626-633. PMID 14654303.
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