Fosfoglicerol geranilgeraniltransferaza
(Preusmjereno sa stranice GGGP synthase)
Fosfoglicerol geranilgeraniltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.5.1.41 | ||||||||
CAS broj | 124650-69-7 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fosfoglicerol geranilgeraniltransferaza (EC 2.5.1.41, glicerol fosfat geranilgeraniltransferaza, geranilgeranil-transferaza, preniltransferaza, (S)-3-O-geranilgeranilgliceril fosfat sintaza, (S)-geranilgeranilgliceril fosfat sintaza, GGGP sintaza, (S)-GGGP sintaza, GGGPS, geranilgeranil difosfat:sn-gliceril fosfat geranilgeraniltransferaza, geranilgeranil difosfat:sn-glicerol-1-fosfat geranilgeraniltransferaza) je enzim sa sistematskim imenom geranilgeranil-difosfat:sn-glicerol-1-fosfat geranilgeraniltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranilgeranil difosfat + sn-glicerol 1-fosfat difosfat + sn-3-O-(geranilgeranil)glicerol 1-fosfat
Ovaj citosolni enzim katalizuje prvi korak biosinteze membranskog dietarskog lipida kod arhabakterija. Za njegovo maksimalno dejstvo je neophodan Mg2+.
- ↑ Zhang, D.-L., Daniels, L. and Poulter, C.D. (1990). „Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction”. J. Am. Chem. Soc. 112: 1264-1265.
- ↑ Chen, A., Zhang, D. and Poulter, C.D. (1993). „(S)-Geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis”. J. Biol. Chem. 268: 21701-21705. PMID 8408023.
- ↑ Nemoto, N., Oshima, T. and Yamagishi, A. (2003). „Purification and characterization of geranylgeranylglyceryl phosphate synthase from a thermoacidophilic archaeon, Thermoplasma acidophilum”. J. Biochem. 133: 651-657. PMID 12801917.
- ↑ Payandeh, J., Fujihashi, M., Gillon, W. and Pai, E.F. (2006). „The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme”. J. Biol. Chem. 281: 6070-6078. PMID 16377641.
- ↑ Morii, H., Nishihara, M. and Koga, Y. (2000). „CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus”. J. Biol. Chem. 275: 36568-36574. PMID 10960477.
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- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
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