DNK-formamidopirimidinska glikozilaza
(Preusmjereno sa stranice DNA glycohydrolase (2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing))
DNK-formamidopirimidinska glikozilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.2.2.23 | ||||||||
CAS broj | 78783-53-6 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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DNK-formamidopirimidinska glikozilaza (EC 3.2.2.23, Fapi-DNK glikozilaza, dezoksiribonukleatna glikozidaza, 2,6-diamino-4-hidroksi-5N-formamidopirimidin-DNK glikozilaza, 2,6-diamino-4-hidroksi-5(N-metil)formamidopirimidin-DNK glikozilaza, formamidopirimidin-DNK glikozilaza, DNK-formamidopirimidinska glikozidaza, Fpg protein) je enzim sa sistematskim imenom DNK glikohidrolaza (2,6-diamino-4-hidroksi-5-(N-metil)formamidopirimidno otpuštanje).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza DNK koja sadrži 7-metilguanin ostataks sa otvorenim prstenom, oslobađa se 2,6-diamino-4-hidroksi-5-(N-metil)formamidopirimidin
Ovaj enzim može da ima značajnu ulogu u procesima koji dovode do oporavka od mutageneze i/ili ćelijske smrti usled dejstva alkilacionih agenasa.
- ↑ Boiteux, S., O'Connor, T.R. and Laval, J. (1987). „Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein”. EMBO J. 6: 3177-3183. PMID 3319582.
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