CCA tRNK nukleotidiltransferaza
CCA tRNK nukleotidiltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.7.7.72 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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CCA tRNK nukleotidiltransferaza (EC 2.7.7.72, enzim CCA dodavanja, tRNK CCA-pirofosforilaza, tRNK-nukleotidiltransferaza, transfer-RNK nukleotidiltransferaza, transfer ribonukleinska kiselina nukleotidil transferaza, CTP(ATP):tRNK nukleotidiltransferaza, transfer ribonukleat adenililtransferaza, transfer ribonukleat adeniltransferaza, transfer RNK adenililtransferaza, transfer ribonukleat nukleotidiltransferaza, ATP (CTP):tRNK nukleotidiltransferaza, ribonukleinska citidilna citidilna adenilna pirofosforilaza, transfer ribonukleinska adenilil (citidilil) transferaza, transfer ribonukleinska-terminal trinukleotid nukleotidiltransferaza, transfer ribonukleat citidililtransferaza, ribonukleinska citidililtransferaza, -C-C-A pirofosforilaza, ATP(CTP)-tRNK nukleotidiltransferaza, tRNK adenilil(citidilil)transferaza, CTP:tRNK citidililtransferaza) je enzim sa sistematskim imenom CTP,CTP,ATP:tRNK citidilil,citidilil,adenililtransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tRNK prekurzor + 2 CTP + ATP tRNK sa 3' CCA krajem + 3 difosfat (sveukupna reakcija)
- (1a) tRNK prekurzor + CTP a tRNK sa 3' citidin krajem + difosfat
- (1b) tRNK sa 3' citidinom + CTP tRNK sa 3' CC krajem + difosfat
- (1c) tRNK sa 3' CC krajem + ATP tRNK sa 3' CCA krajem + difosfat
Acilacija svih tRNK molekula aminokiselinom odvija se na terminalnoj ribozi 3' CCA sekvence.
- ↑ Schofield, P. and Williams, K.R. (1977). „Purification and some properties of Escherichia coli tRNA nucleotidyltransferase”. J. Biol. Chem. 252: 5584-5588. PMID 328503.
- ↑ Shi, P.Y., Maizels, N. and Weiner, A.M. (1998). „CCA addition by tRNA nucleotidyltransferase: polymerization without translocation”. EMBO J. 17: 3197-3206. PMID 9606201.
- ↑ Augustin, M.A., Reichert, A.S., Betat, H., Huber, R., Morl, M. and Steegborn, C. (2003). „Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization”. J. Mol. Biol. 328: 985-994. PMID 12729736.
- ↑ Yakunin, A.F., Proudfoot, M., Kuznetsova, E., Savchenko, A., Brown, G., Arrowsmith, C.H. and Edwards, A.M. (2004). „The HD domain of the Escherichia coli tRNA nucleotidyltransferase has 2′,3′-cyclic phosphodiesterase, 2′-nucleotidase, and phosphatase activities”. J. Biol. Chem. 279: 36819-36827. PMID 15210699.
- ↑ Hou, Y.M. (2010). „CCA addition to tRNA: implications for tRNA quality control”. IUBMB Life 62: 251-260. PMID 20101632.
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