CMP-N-acetilneuraminat monooksigenaza
(Preusmjereno sa stranice CMP-N-acetylneuraminic acid hydroxylase)
CMP-N-acetilneuraminat monooksigenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.14.18.2 | ||||||||
CAS broj | 116036-67-0 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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CMP-N-acetilneuraminat monooksigenaza (EC 1.14.18.2, CMP-N-acetilneuraminska kiselina hidroksilaza, CMP-Neu5Ac hidroksilaza, citidin monofosfoacetilneuraminatna monooksigenaza, N-acetilneuraminska monooksigenaza, citidin-5'-monofosfat-N-acetilneuraminska kiselina hidroksilaza) je enzim sa sistematskim imenom CMP-N-acetilneuraminat,ferocitohrom-b5:kiseonik oksidoreduktaza (N-acetil-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- CMP-N-acetilneuraminat + 2 ferocitohrom b5 + O2 + 2 H+ CMP-N-glikoloilneuraminat + 2 fericitohrom b5 + H2O
Ovaj enzim sadrži Riskijev tip [2Fe-2S] klastera i jedan dodatno mesto vezivanja gvožđa.
- ↑ Shaw, L. and Schauer, R. (1988). „The biosynthesis of N-glycoloylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid”. Biol. Chem. Hoppe-Seyler 369: 477-486. PMID 3202954.
- ↑ Kozutsumi, Y., Kawano, T., Yamakawa, T. and Suzuki, A. (1990). „Participation of cytochrome b5 in CMP-N-acetylneuraminic acid hydroxylation in mouse liver cytosol”. J. Biochem. (Tokyo) 109: 704-706. PMID 1964451.
- ↑ Schneckenburger, P., Shaw, L. and Schauer, R. (1994). „Purification, characterization and reconstitution of CMP-N-acetylneuraminate hydroxylase from mouse liver”. Glycoconj. J. 11: 194-203. PMID 7841794.
- ↑ Kawano, T., Koyama, S., Takematsu, H., Kozutsumi, Y., Kawasaki, H., Kawashima, S., Kawasaki, T. and Suzuki, A. (1995). „Molecular cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase. Regulation of species- and tissue-specific expression of N-glycolylneuraminic acid”. J. Biol. Chem. 270: 16458-16463. PMID 7608218.
- ↑ Schlenzka, W., Shaw, L., Kelm, S., Schmidt, C.L., Bill, E., Trautwein, A.X., Lottspeich, F. and Schauer, R. (1996). „CMP-N-acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron-sulphur protein to be described in Eukarya”. FEBS Lett. 385: 197-200. PMID 8647250.
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