B-galaktozid a-2,3-sijaliltransferaza
(Preusmjereno sa stranice CMP-N-acetylneuraminate:beta-D-galactoside alpha-(2-3)-N-acetylneuraminyl-transferase)
B-galaktozid a-2,3-sijaliltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.4.99.4 | ||||||||
CAS broj | 71124-51-1 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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B-galaktozid a-2,3-sijaliltransferaza (EC 2.4.99.4, CMP-N-acetilneuraminat:beta-D-galaktozid alfa-2,3-N-acetilneuraminil-transferaza) je enzim sa sistematskim imenom CMP-N-acetilneuraminat:beta-D-galaktozid alfa-(2->3)-N-acetilneuraminil-transferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- CMP-N-acetilneuraminat + beta-D-galaktozil-(1->3)-N-acetil-alfa-D-galaktozaminil-R CMP + alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozil-(1->3)-N-acetil-alfa-D-galaktozaminil-R
Akceptor je Galbeta1,3GalNAc-R, gde je R: H, treoninski ili serinski ostatak glikoproteina, ili glikolipida. Laktoza takođe može da deluje kao akceptor.
- ↑ Rearick, J.I., Sadler, J.E., Paulson, J.C. and Hill, R.L. (1979). „Enzymatic characterization of β D-galactoside α2→3 sialyltransferase from porcine submaxillary gland”. J. Biol. Chem. 254: 4444-4451. PMID 438198.
- ↑ Sadler, J.E., Rearick, J.I., Paulson, J.C. and Hill, R.L. (1979). „Purification to homogeneity of a β-galactoside α2→3 sialyltransferase and partial purification of an α-N-acetylgalactosaminide α2→6 sialyltransferase from porcine submaxillary glands”. J. Biol. Chem. 254: 4434-4442. PMID 438196.
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