(KDO)2-lipid IVA (2-8) 3-dezoksi-D-mano-oktulozonska kiselina transferaza
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(KDO)2-lipid IVA (2-8) 3-dezoksi-D-mano-oktulozonska kiselina transferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.4.99.14 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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(KDO)2-lipid IVA (2-8) 3-dezoksi-D-mano-oktulozonska kiselina transferaza (EC 2.4.99.14, KDO transferaza, waaA (gen), kdtA (gen), 3-dezoksi-D-mano-okt-2-ulozonska kiselina transferaza, 3-dezoksi-mano-oktulozonska kiselina transferaza) je enzim sa sistematskim imenom CMP-3-dezoksi-D-mano-okt-2-ulozonat:(KDO)2-lipid IVA 3-dezoksi-D-mano-okt-2-ulozonat transferaza ((2->8) formira glikozidnu vezu).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + CMP-alfa-Kdo alfa-Kdo-(2->8)-alfa-Kdo-(2->4)-alfa-Kdo-(2->6)-lipid IVA + CMP
Enzimi iz Chlamydia prenose tri ili više 3-dezoksi-D-mano-okt-2-ulozonatna ostatka i formiraju genus-specifične epitope.
- ↑ Lobau, S., Mamat, U., Brabetz, W. and Brade, H. (1995). „Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183”. Mol. Microbiol. 18: 391-399. PMID 8748024.
- ↑ Mamat, U., Baumann, M., Schmidt, G. and Brade, H. (1993). „The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology”. Mol. Microbiol. 10: 935-941. PMID 7523826.
- ↑ Belunis, C.J., Mdluli, K.E., Raetz, C.R. and Nano, F.E. (1992). „A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope”. J. Biol. Chem. 267: 18702-18707. PMID 1382060.
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